Around 2,000 people took to the streets shouting anti-government slogans and demanding action against the extremist attackers.
Protesters gathered outside Isfahan's judiciary compared the attackers to ISIS militants. Others chanted, "Death to extremists."
The protests were organized in the wake of a new law passed Sunday which is designed to protect and empower citizens who "correct" those that do not adhere to Iran's strict social laws and who display un-Islamic behavior.
The mullah's regime is using "brutalities and intimidation" against those who are increasingly becoming critical of them, said Maryam Rajavi, President-elect of the National Council of Resistance of Iran (NCRI).
Protesters and opposition forces say the women have been attacked under the pretext of "mal-veiling" — a term used by the country's religious authorities to describe clothing that does not meet Islamic standards.
Tasneem Nashrulla is a reporter for BuzzFeed News and is based in New York.