According to the El País newspaper, two people opened fire on guests at a hotel before fleeing.
Coups de feu en plein après-midi à 50 mètres de la Rambla de Barcelone. Plusieurs blessés.
La Vanguardia reported the shooting took place at the Hotel Silken, near the intersection of La Rambla and Pinto Fortuny street.
Tweets from those on scene showed police outside the building.
#BCN Los disparos se han producido frente a este hotel de Pintor Fortuny con Rambla
El País reported one person was seriously injured, while another person had knife wounds.
UPDATE: Areas of Barcelona's La Rambla pedestrian mall cordoned off as police search for suspects in hotel shooting.
Police have reportedly searched a nearby supermarket as the continue their manhunt.
IN PHOTOS: Aftermath of shooting in Barcelona's La Rambla (captions in Catalan) http://t.co/6q7Q15DrDX
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